In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …

Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising
globally, the reasons for which are unclear. It appears to represent a unique disease …

Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need,
especially as diagnosis in this population might lead to the greatest loss of years of life …

Endometrial disorders represent a major gynaecological burden. Current research models
fail to recapitulate the nature and heterogeneity of these diseases, thereby hampering …

Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality
worldwide. Its complexity is influenced by various signal transduction networks that govern …

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We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to
examine shared and distinguishing molecular characteristics of gastrointestinal tract …

Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …