Abstract The Ca2+-sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …

Metastasis is a final stage of tumor progression. Breast and prostate cancer cells
preferentially metastasize to bone, wherein they cause incurable osteolytic and osteoblastic …

Abstract Myelination of Schwann cells (SCs) is critical for the success of peripheral nerve
regeneration, and biomaterials that can promote SCs' neurotrophin secretion as scaffolds …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

Strontium ranelate exerts both an anti-catabolic and an anabolic effect on bone cells. To
further investigate the molecular mechanism whereby strontium ranelate inhibits bone …

The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

Compelling evidence of a cell surface receptor sensitive to extracellular calcium was
observed as early as the 1980s and was finally realized in 1993 when the calcium-sensing …

γ-Glutamyl peptides (γ-GPs) are a group of peptides naturally found in various food sources.
The unique γ-bond potentially enables them to resist gastrointestinal digestion and offers …

The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by
regulating parathyroid hormone secretion and urinary calcium excretion. The CaSR is …

The identification of the calcium-sensing receptor (CaSR) and the clarification of its role as
the major regulator of parathyroid gland function have important implications for …