Patient-derived xenograft models in cancer therapy: technologies and applications
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
The blood–tumour barrier in cancer biology and therapy
PS Steeg - Nature Reviews Clinical Oncology, 2021 - nature.com
The protective blood–brain barrier has a major role in ensuring normal brain function by
severely limiting and tightly controlling the ingress of substances into the brain from the …
severely limiting and tightly controlling the ingress of substances into the brain from the …
Prognostic and predictive biomarkers in gliomas
P Śledzińska, MG Bebyn, J Furtak… - International journal of …, 2021 - mdpi.com
Gliomas are the most common central nervous system tumors. New technologies, including
genetic research and advanced statistical methods, revolutionize the therapeutic approach …
genetic research and advanced statistical methods, revolutionize the therapeutic approach …
Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma
Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance
In patients with glioblastoma, resistance to the chemotherapeutic temozolomide (TMZ) limits
any survival benefits conferred by the drug. Here we show that the convection-enhanced …
any survival benefits conferred by the drug. Here we show that the convection-enhanced …
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine
Abstract Background N6-methyladenosine (m6A) is the most prevalent messenger RNA
modification in mammalian cells. However, the disease relevant function of m6A on specific …
modification in mammalian cells. However, the disease relevant function of m6A on specific …
Mouse models of glioblastoma for the evaluation of novel therapeutic strategies
Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …
months despite an aggressive standard of care that includes surgery, chemotherapy, and …
A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …
gliomas, and our understanding of drug transport across this critical biointerface remains …
The many facets of therapy resistance and tumor recurrence in glioblastoma
Glioblastoma (GBM) is the most lethal type of primary brain cancer. Standard care using
chemo-and radio-therapy modestly increases the overall survival of patients; however …
chemo-and radio-therapy modestly increases the overall survival of patients; however …
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
Patient-based cancer models are essential tools for studying tumor biology and for the
assessment of drug responses in a translational context. We report the establishment a large …
assessment of drug responses in a translational context. We report the establishment a large …