The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

The use of synthetic, natural, or biological agents to minimize the occurrence of cancer in
healthy individuals is defined as cancer chemoprevention. Chemopreventive agents inhibit …

The ethnomedical uses of Piper (胡椒Hú Jiāo) plants as anticancer agents, in vitro cytotoxic
activity of both extracts and compounds from Piper plants, and in vivo antitumor activity and …

Accumulating evidence indicates that senescent cells play an important role in many age-
associated diseases. The pharmacological depletion of senescent cells (SCs) with a …

Considered as the second deadliest disease globally, cancer has captured the attention of
researchers who have been trying with perseverance to decode its hidden aspects, to find …

Piperlongumine, a white to beige biologically active alkaloid/amide phytochemical, has high
pharmacological relevance as an anticancer agent. Piperlongumine has several biological …

The global incidence of cancer and cancer‐related mortality is expected to rise in recent
years despite advancements in cancer diagnosis and therapeutics. Increasing evidences of …

Drug repurposing is a valuable approach in delivering new cancer therapeutics rapidly into
the clinic. Existing safety and patient tolerability data for drugs already in clinical use …

Colorectal cancer (CRC) is the most common carcinoma of the digestive tract. The slow
growing nature of CRC offers a great opportunity for prevention strategies. The concept of …

Piperlongumine (PL), a herbal drug extracted from long pepper (Piper longum L), is known
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …