Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …

For decades, common chemotherapeutic drugs have been established to trigger apoptosis,
the preferred immunologically “silent” form of cell death. The primary objective of this review …

Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of …

Death-associated protein kinase (DAPk) is the founding member of a newly classified family
of Ser/Thr kinases, whose members not only possess significant homology in their catalytic …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

Netrin-1, an axon navigation cue was proposed to play a crucial role during colorectal
tumorigenesis by regulating apoptosis. The netrin-1 receptors DCC and UNC5H were …

Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even
though a few Food and Drug Administration approved STKs inhibitors are reported. The third …

Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …

Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …