[HTML][HTML] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …
guidelines for the definition and interpretation of cell death from morphological, biochemical …
Metastasis: a question of life or death
P Mehlen, A Puisieux - Nature reviews cancer, 2006 - nature.com
The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …
Apoptosis, necroptosis, and pyroptosis as alternative cell death pathways induced by chemotherapeutic agents?
For decades, common chemotherapeutic drugs have been established to trigger apoptosis,
the preferred immunologically “silent” form of cell death. The primary objective of this review …
the preferred immunologically “silent” form of cell death. The primary objective of this review …
[HTML][HTML] Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy
Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of …
(Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of …
The death-associated protein kinases: structure, function, and beyond
S Bialik, A Kimchi - Annu. Rev. Biochem., 2006 - annualreviews.org
Death-associated protein kinase (DAPk) is the founding member of a newly classified family
of Ser/Thr kinases, whose members not only possess significant homology in their catalytic …
of Ser/Thr kinases, whose members not only possess significant homology in their catalytic …
Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
P Mehlen, C Delloye-Bourgeois, A Chédotal - Nature Reviews Cancer, 2011 - nature.com
Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …
for embryogenesis have been shown to regulate tumour development and progression by …
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
J Fitamant, C Guenebeaud… - Proceedings of the …, 2008 - National Acad Sciences
Netrin-1, an axon navigation cue was proposed to play a crucial role during colorectal
tumorigenesis by regulating apoptosis. The netrin-1 receptors DCC and UNC5H were …
tumorigenesis by regulating apoptosis. The netrin-1 receptors DCC and UNC5H were …
Death‐associated protein kinase (DAPK) family modulators: current and future therapeutic outcomes
AK Farag, EJ Roh - Medicinal Research Reviews, 2019 - Wiley Online Library
Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even
though a few Food and Drug Administration approved STKs inhibitors are reported. The third …
though a few Food and Drug Administration approved STKs inhibitors are reported. The third …
Dependence receptors: a new paradigm in cell signaling and cancer therapy
D Goldschneider, P Mehlen - Oncogene, 2010 - nature.com
Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …
that are not linked by their structure, but by common functional traits. The most notable is …
[HTML][HTML] Structural decoding of the Netrin-1/UNC5 interaction and its therapeutical implications in cancers
M Grandin, M Meier, JG Delcros, D Nikodemus… - Cancer cell, 2016 - cell.com
Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …