The structure of the adeno-associated virus (AAV-2) has been determined to 3-Å resolution
by x-ray crystallography. AAV is being developed as a vector for gene therapy to treat …

Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The
crystal structure of the T= 4 capsid has been solved at 3.3 Å resolution, revealing a largely …

Abstract Monoamine oxidase B (MAO B) is a mitochondrial outermembrane flavoenzyme
that is a well-known target for antidepressant and neuroprotective drugs. We determined the …

Compartmentalization is an important organizational feature of life. It occurs at varying levels
of complexity ranging from eukaryotic organelles and the bacterial microcompartments, to …

Pore-forming toxins (PFTs) are a class of potent virulence factors that convert from a soluble
form to a membrane-integrated pore. They exhibit their toxic effect either by destruction of …

The crystal structure of DsRed, a red fluorescent protein from a corallimorpharian, has been
determined at 2.0-Å resolution by multiple-wavelength anomalous dispersion and …

Ubiquitin binding proteins regulate the stability, function, and/or localization of ubiquitinated
proteins. Here we report the crystal structures of the zinc-finger ubiquitin binding domain …

Our knowledge of biological macromolecules and their interactions is based on the
application of physical methods, ranging from classical thermodynamics to recently …

Carotenoids undergo a wide range of photochemical reactions in animal, plant, and
microbial systems. In photosynthetic organisms, in addition to light harvesting, they perform …

Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and
young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike …