Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

The SARS (severe acute respiratory syndrome) outbreak was caused by a coronavirus
(CoV) named the SARS-CoV. SARS pathology is propagated both by direct cytotoxic effects …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

Abstract N6‑methyladenosine (m6A) is the most prevalent and abundant type of internal post‑
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …

Lysosomes are the main organelles in macrophages for killing invading bacteria. However,
the precise mechanism underlying lysosomal biogenesis upon bacterial infection remains …

ABSTRACT N6-methyladenosine (m6A) mRNA modifications play critical roles in various
biological processes. However, no study addresses the role of m6A in macroautophagy …

Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …