Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …

Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …

To date, an effective therapeutic treatment that confers strong attenuation toward
coronaviruses (CoVs) remains elusive. Of all the potential drug targets, the helicase of CoVs …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

The suggestion that the native state of many proteins is intrinsically disordered (or, as
originally termed, unstructured) is now integral to our general view of protein structure and …

Helicases of the superfamily (SF) 1 and 2 are involved in virtually all aspects of RNA and
DNA metabolism. SF1 and SF2 helicases share a catalytic core with high structural …

Although most mRNA molecules derived from protein-coding genes are destined to be
translated into functional polypeptides, some are eliminated by cellular quality control …

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …

Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …

RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all
aspects of RNA metabolism. These proteins bind or remodel RNA or RNA–protein …