Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis, non-alcoholic
steatohepatitis (NASH), and progressive liver fibrosis is considered the most common liver …

The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

Insulin resistance is often associated with impeded insulin signaling due either to decreased
concentrations or functional modifications of crucial signaling molecules including insulin …

Background: Inflammation is pivotal in all phases of atherosclerosis. Among the numerous
inflammatory biomarkers, the largest amount of published data supports a role for C-reactive …

It is well established that adipose tissue, apart from its energy storage function, acts as an
endocrine organ that produces and secretes a number of bioactive substances, including …

Comprehensive characterization of human tissues promises novel insights into the
biological architecture of human diseases and traits. We assessed metabonomic …

The AMP-activated protein kinase (AMPK) was initially identified as the kinase that
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …

Non-communicable diseases like cardiovascular diseases, cerebrovascular diseases,
diabetes mellitus, and cancer are very common causes of death worldwide. Therefore, the …

Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities,
with inflammation playing an important role in downregulating APN production. In contrast to …

Accumulating epidemiologic evidence has revealed that metabolic syndrome is an
independent risk factor for psoriasis development and is associated with more severe …