Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for
personalized medicine. In the last decade, major chemical developments and improvements …

Hyperlipidemia is a well-established risk factor for developing cardiovascular disease
(CVD). The recent American College of Cardiology and American Heart Association …

Thousands of long non-coding RNAs (lncRNAs) have been identified in mammalian cells.
Some have important functions and their dysregulation can contribute to a variety of disease …

Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has
attracted a lot of attention from the scientific community and pharmaceutical companies …

The mammalian proprotein convertases constitute a family of nine secretory serine
proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein …

PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL
cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL …

Hypercholesterolemia is a major risk factor for cardiovascular diseases, increasing the
incidence of myocardial infarction and death. Statin-induced lowering of low-density …

Statins are the most-effective therapy currently available for lowering the LDL-cholesterol
(LDL-C) level and preventing cardiovascular events. Additional therapies are necessary for …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the
regulation of cholesterol homeostasis. By binding to hepatic low-density lipoprotein (LDL) …