This review is aimed at providing readers with a comprehensive reference article about the
distribution and function of P2 receptors in all the organs, tissues, and cells in the body …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Evidence for the role of purinergic signaling (via P1 and P2Y receptors) in the proliferation of
vascular smooth muscle and endothelial cells is reviewed. The involvement of the mitogen …

Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …

The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor
subtypes is described. This is followed by a summary of what is known of the distribution and …

Cell-based assays are more complex than cell-free test systems but still reflect a highly
artificial cellular environment. Incorporation of organotypic 3-dimensional (3-D) culture …

Abstract Purpose: Regulatory T cell (Treg) frequency and activity are increased in cancer
patients and play a major role in tumor escape. Although disease progression is favored by …

Cancer is still one of the world's most pressing health-care challenges, leading to a high
number of deaths worldwide. Immunotherapy is a new developing therapy that boosts …

The involvement of P2Y receptors, which are activated by extracellular nucleotides, in
proliferative regulation of human lung epithelial cells is unclear. Here we show that …