▪ Abstract The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly
homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a …

COP9 Signalosome (CSN) is a fascinating protein complex whose biochemical and
physiological functions are only beginning to be understood. It is conserved throughout …

The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens
and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities …

The C. elegans germ line proliferates from one primordial germ cell (PGC) set aside in the
early embryo to over a thousand cells in the adult. Most germline proliferation is controlled …

Here we present the first global functional analysis of cellular responses to pore-forming
toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single …

The p38 and JNK classes of mitogen-activated protein kinases (MAPKs) have evolutionarily
conserved roles in the control of cellular responses to microbial and abiotic stresses. The …

Mitogen‐activated protein kinases (MAPKs) are integral to the mechanisms by which cells
respond to physiological stimuli and to a wide variety of environmental stresses. MAPK …

Jab1 interacts with a variety of signaling molecules and regulates their stability in
mammalian cells. As the fifth component of the COP9 signalosome (CSN) complex, Jab1 …

Caenorhabditis elegans has become a powerful experimental organism with which to study
meiotic processes that promote the accurate segregation of chromosomes during the …

The COP9 signalosome (CSN) is a multiprotein complex of the ubiquitin–proteasome
pathway. CSN is typically composed of eight subunits, each of which is related to one of the …