[PDF][PDF] Biliary atresia: clinical and research challenges for the twenty‐first century

JA Bezerra, RG Wells, CL Mack, SJ Karpen… - …, 2018 - Wiley Online Library
Biliary atresia (BA) is a fibroinflammatory disease of the intrahepatic and extrahepatic biliary
tree. Surgical hepatic portoenterostomy (HPE) may restore bile drainage, but progression of …

Biliary atresia and other cholestatic childhood diseases: advances and future challenges

HJ Verkade, JA Bezerra, M Davenport… - Journal of …, 2016 - Elsevier
Biliary Atresia and other cholestatic childhood diseases are rare conditions affecting the
function and/or anatomy along the canalicular-bile duct continuum, characterised by onset of …

Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia

C Lertudomphonwanit, R Mourya, L Fei… - Science translational …, 2017 - science.org
Biliary atresia is a progressive infantile cholangiopathy of complex pathogenesis. Although
early diagnosis and surgery are the best predictors of treatment response, current diagnostic …

Identification of a plant isoflavonoid that causes biliary atresia

K Lorent, W Gong, KA Koo… - Science translational …, 2015 - science.org
Biliary atresia (BA) is a rapidly progressive and destructive fibrotic disorder of unknown
etiology affecting the extrahepatic biliary tree of neonates. Epidemiological studies suggest …

[HTML][HTML] Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

M Reich, L Spomer, C Klindt, K Fuchs, J Stindt… - Journal of …, 2021 - Elsevier
Abstract Background&Aims Primary sclerosing cholangitis (PSC) is characterized by chronic
inflammation and progressive fibrosis of the biliary tree. The bile acid receptor TGR5 is …

Quantification of serum matrix metallopeptide 7 levels may assist in the diagnosis and predict the outcome for patients with biliary atresia

JF Wu, YM Jeng, HL Chen, YH Ni, HY Hsu… - The Journal of …, 2019 - Elsevier
Objective To assess the diagnostic and prognostic usefulness of the serum matrix
metallopeptidase-7 (MMP-7) level for biliary atresia in infants with cholestasis after …

[HTML][HTML] Biomarkers for the diagnosis and post-Kasai portoenterostomy prognosis of biliary atresia: a systematic review and meta-analysis

L He, DKM Ip, G Tam, VCH Lui, PKH Tam… - Scientific reports, 2021 - nature.com
To evaluate the accuracy of biomarkers for the early diagnosis of biliary atresia (BA) and
prognostic stratification after Kasai portoenterostomy (KPE). We conducted a systematic …

[PDF][PDF] Biliary atresia in children: update on disease mechanism, therapies, and patient outcomes

S Antala, SA Taylor - Clinics in liver disease, 2022 - Elsevier
Biliary atresia is a rare disease but remains the most common indication for pediatric liver
transplantation as there are no effective medical therapies to slow progression after …

[PDF][PDF] Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy

JF Wu, CS Lee, WH Lin, YM Jeng, HL Chen, YH Ni… - …, 2018 - Wiley Online Library
We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in
cholestatic infants and predicting the outcome of BA. Forty‐eight cholestatic infants (9‐87 …

Single‐cell and spatial transcriptomics reveal the fibrosis‐related immune landscape of biliary atresia

C Ye, J Zhu, J Wang, D Chen, L Meng… - Clinical and …, 2022 - Wiley Online Library
Background Biliary atresia (BA) is a devastating inflammatory and fibrosing cholangiopathy
of neonates with unknown aetiology. We aim to investigate the relationship between these …