Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Cytoskeletal filamentous actin (F-actin) has long been considered a molecule that may
regulate exo-and endocytosis. However, its exact roles remained elusive. Recent studies …

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease,
which has a high heritability of up to 79%. Exploring the genetic basis is essential for …

Membrane fusion and budding mediate fundamental processes like intracellular trafficking,
exocytosis, and endocytosis. Fusion is thought to open a nanometer-range pore that may …

Endo-and exocytosis proceed through a highly strained membrane fusion pore topology
regardless of the aiding protein machinery. The membrane's lipid components bias fusion …

Membrane budding entails forces to transform flat membrane into vesicles essential for cell
survival. Accumulated studies have identified coat-proteins (eg, clathrin) as potential …

Vesicle fusion at preestablished plasma membrane release sites releases transmitters and
hormones to mediate fundamental functions like neuronal network activities and fight-or …

Clathrin-mediated endocytosis, the most prominent endocytic mode, is thought to be
generated primarily from relatively flat patches of the plasma membrane. By employing …

Membrane budding, which underlies fundamental processes like endocytosis, intracellular
trafficking, and viral infection, is thought to involve membrane coat-forming proteins …

Following calcium-triggered vesicle exocytosis, endocytosis regenerates vesicles to
maintain exocytosis and thus synaptic transmission, which underlies neuronal circuit …