Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …

One week after fertilization, human embryos implant into the uterus. This event requires the
embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo …

In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …

Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …

Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …

Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and
hypoblast. Here we describe a human embryo model (blastoid) generated by self …

CellProfiler has enabled the scientific research community to create flexible, modular image
analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new …