Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and
essential to chromosome stability/integrity. In normal human cells, telomere length erodes …

Telomerase reverse transcriptase (TERT) is the catalytic subunit of the enzyme telomerase
and is essential for telomerase activity. Upregulation of TERT expression and resulting …

Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy
characterized by dysregulated cellular metabolism leading to aberrant glucose metabolism …

Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin
structures for genome protection and replication. Telomere length maintenance has been …

The transcriptional de-repression of the telomerase reverse transcriptase (TERT) gene and
subsequent activation of telomerase is a prerequisite step in malignant transformation and …

Telomerase, an RNA-dependent DNA polymerase with telomerase reverse transcriptase
(TERT) as the catalytic component, is silent due to the tight repression of the TERT gene in …

Telomerase is an enzyme which is culpable for the aliment and stability of telomeres. It also
maintains the genomic integrity and chromosomal stability. The progressive shortening of …

Differentiated thyroid cancer (DTC) is a rare disease in the paediatric population (≤ 18
years old. at diagnosis). Increasing incidence is reflected by increases in incidence for …