The emerging mechanisms and functions of microautophagy
Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
[HTML][HTML] Selective autophagy of intracellular organelles: recent research advances
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …
that degrades over-abundant or damaged organelles, large protein aggregates and …
Crosstalk between mammalian autophagy and the ubiquitin-proteasome system
NM Kocaturk, D Gozuacik - Frontiers in cell and developmental …, 2018 - frontiersin.org
Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
The lysosome as an imperative regulator of autophagy and cell death
KK Mahapatra, SR Mishra, BP Behera, S Patil… - Cellular and Molecular …, 2021 - Springer
Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …
Research advances in the mechanisms of hyperuricemia‐induced renal injury
H Su, C Yang, D Liang, H Liu - BioMed Research International, 2020 - Wiley Online Library
Uric acid is the end product of purine metabolism in humans, and its excessive accumulation
leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys …
leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys …
Targeting the lysosome in cancer
S Piao, RK Amaravadi - Annals of the New York Academy of …, 2016 - Wiley Online Library
Lysosomes are membrane‐bound intracellular organelles that receive macromolecules
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …
delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over …
Detection and clearance of damaged lysosomes by the endo-lysosomal damage response and lysophagy
C Papadopoulos, H Meyer - Current Biology, 2017 - cell.com
Lysosomal membrane permeabilization or lysosomal rupture is recognized as a common
and severe stress condition relevant for infection, cellular degeneration and cancer …
and severe stress condition relevant for infection, cellular degeneration and cancer …
Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles
Nanoparticles (NPs) typically accumulate in lysosomes. However, their impact on lysosomal
function, as well as autophagy, a lysosomal degradative pathway, is still not well known. We …
function, as well as autophagy, a lysosomal degradative pathway, is still not well known. We …
SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy
Macroautophagy/autophagy dysregulation has been noted in diabetic nephropathy;
however, the regulatory mechanisms controlling this process remain unclear. In this study …
however, the regulatory mechanisms controlling this process remain unclear. In this study …
The role of cysteine cathepsins in cancer progression and drug resistance
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their
expression is misregulated in a wide variety of tumors, and ample data prove their …
expression is misregulated in a wide variety of tumors, and ample data prove their …