Small Noncoding RNAs and Their Role in the Pathogenesis of Mycobacterium tuberculosis Infection

AA Ostrik, TL Azhikina, EG Salina - Biochemistry (Moscow), 2021 - Springer
Mycobacterium tuberculosis possesses a significant arsenal of strategies to combat immune
defense of the host organism. Small noncoding RNAs, which constitute the largest group of …

Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection

WJ Brewer, AM Xet-Mull, A Yu, MI Sweeney… - Cell reports, 2022 - cell.com
During mycobacterial infections, pathogenic mycobacteria manipulate both host immune
and stromal cells to establish and maintain a productive infection. In humans, non-human …

Commonalities of Mycobacterium tuberculosis Transcriptomes in Response to Defined Persisting Macrophage Stresses

C Vilchèze, B Yan, R Casey, S Hingley-Wilson… - Frontiers in …, 2022 - frontiersin.org
As the goal of a bacterium is to become bacteria, evolution has imposed continued
selections for gene expression. The intracellular pathogen Mycobacterium tuberculosis, the …

Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease

ID Gaudet, H Xu, E Gordon, GA Cannestro… - Journal of …, 2024 - Springer
We previously identified solute carrier family 7 member 2 (SLC7A2) as one of the top
upregulated genes when normal Huntingtin was deleted. SLC7A2 has a high affinity for l …

Diagnosis of pulmonary tuberculosis via identification of core genes and pathways utilizing blood transcriptional signatures: a multicohort analysis

Q Qiu, A Peng, Y Zhao, D Liu, C Liu, S Qiu, J Xu… - Respiratory …, 2022 - Springer
Background Blood transcriptomics can be used for confirmation of tuberculosis diagnosis or
sputumless triage, and a comparison of their practical diagnostic accuracy is needed to …

Mycoplasma genitalium and M. pneumoniae Regulate a Distinct Set of Protein-Coding Genes in Epithelial Cells

EI Ramos, K Das, AL Harrison, A Garcia… - Frontiers in …, 2021 - frontiersin.org
Mycoplasma genitalium and M. pneumoniae are two significant mycoplasmas that infect the
urogenital and respiratory tracts of humans. Despite distinct tissue tropisms, they both have …

Mycobacterium tuberculosis infection triggers epigenetic changes that are enriched in a type I IFN signature

K Madden, R El Hamra, S Berton, J Felker… - …, 2023 - academic.oup.com
Tuberculosis, a deadly infectious lung disease caused by Mycobacterium tuberculosis (Mtb),
remains the leading cause of bacterial disease-related deaths worldwide. Mtb reprograms …

Advances in computational frameworks in the fight against TB: The way forward

A Naidu, SS Nayak, S Lulu S… - Frontiers in …, 2023 - frontiersin.org
Around 1.6 million people lost their life to Tuberculosis in 2021 according to WHO estimates.
Although an intensive treatment plan exists against the causal agent, Mycobacterium …

Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages

G Xiao, S Zhang, L Zhang, S Liu, G Li, M Ou, X Zeng… - BMC microbiology, 2022 - Springer
Background Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) remains a
global health issue. The characterized virulent M. tb H37Rv, avirulent M. tb H37Ra and BCG …

Genome-wide association analysis identified both RNA-seq and DNA variants associated to paratuberculosis in Canadian Holstein cattle 'in vitro'experimentally …

O Ariel, JS Brouard, A Marete, F Miglior… - BMC genomics, 2021 - Springer
Background Mycobacterium avium ssp. paratuberculosis (MAP) is the causative agent of
paratuberculosis, or Johne's disease (JD), an incurable bovine disease. The evidence for …