The discovery of the genetic roots of various human diseases has motivated the exploration
of different exogenous nucleic acids as therapeutic agents to treat these genetic disorders …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

Polyelectrolyte complex (PEC) nanoparticles assembled from plasmid DNA (p DNA) and
polycations such as linear polyethylenimine (l PEI) represent a major nonviral delivery …

The objective of the present study is to conjugate L-thyroxine PEI derivative onto another PEI
to compensate the amine content of the whole structure which has been utilized for the …

Recent years have witnessed rapidly growing interest in application of gene therapies for
cancer treatment. However, this strategy requires nucleic acid carriers that are both effective …

Polyethylenimine (PEI) is one of the most broadly used polycations for gene delivery due to
its high transfection efficiency and commercial availability but materials are cytotoxic and …

There has been a rapidly growing interest in the use of functionalized Au nanoparticles
(NPs) as platforms in multiple applications in medicine and manufacturing. The sensing and …

Polyplexes composed of polyethyleneimine (PEI) and DNA or siRNA have attracted great
attention for their use in gene therapy. Although many physicochemical characteristics of …

A series of surfactant-like peptides have been designed for inducing DNA condensation,
which are all comprised of the same set of amino acids in different sequences. Results from …

Previously, we revealed that in the application of using cationic polymer chains,
polyethylenimine (PEI), to condense anionic plasmid DNA chains (pDNA) to form the …