Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Our immune system has evolved as a complex network of cells and tissues tasked with
maintaining host homeostasis. This is evident during the inflammatory responses elicited …

Major depressive disorder (MDD) is a devastating mental disorder that affects up to 17% of
the population worldwide. Although brain-wide network-level abnormalities in MDD patients …

Background Substance use disorders are associated with disruptions in circadian rhythms.
Both human and animal work have shown the integral role for circadian clocks in the …

Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens
(NAc). However, no studies to date have investigated cell type-specific transcriptomic …

The endocannabinoid system (ECS) is involved in a variety of brain functions, mainly
through the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly …

Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

The review integrates different experimental approaches including biochemistry, c-Fos
expression, microdialysis (glutamate, GABA, noradrenaline and serotonin) …

The opioid epidemic is a growing public concern affecting millions of people worldwide.
Opioid-induced reward is the initial and key process leading to opioid abuse and addiction …

Substance abuse and addiction represent a significant public health problem that impacts
multiple dimensions of society, including healthcare, the economy, and the workforce. In …