We report our recent development of a conceptually new generation of exceptionally potent
non-peptidic HIV-1 protease inhibitors that displayed excellent pharmacological and drug …

COVID-19 caused by SARS-CoV-2 has continually been serious threat to public health
worldwide. While a few anti-SARS-CoV-2 therapeutics are currently available, their antiviral …

Potent and biostable inhibitors of the main protease (M pro) of SARS-CoV-2 were designed
and synthesized based on an active hit compound 5h (2). Our strategy was based not only …

Alzheimer's disease is becoming a growing problem increasing at a tremendous rate.
Serotonin 5-HT 6 receptors appear to be a particularly attractive target from a therapeutic …

A facile and highly efficient iodine-promoted strategy has been delineated for the synthesis
of indolo and pyrrolo [1, 2-a] quinoxaline derivatives via an oxidative Pictet–Spengler type …

HIV-1 protease (PR) plays a crucial role in the treatment of HIV as a key target. The global
issue of emerging drug resistance is escalating, and PR mutations pose a substantial …

HIV-associated lipodystrophy has been reported in people taking anti-retroviral therapy
(ART). Lipodystrophy can cause cardiovascular diseases, affecting the quality of life of HIV …

Darunavir (DRV) is exceptional among potent HIV-1 protease inhibitors (PIs) in high drug
concentrations that are achieved in vivo. Little is known about the de novo resistance …

Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome
(AIDS) still claim many lives across the world. However, research efforts during the last 40 …

A Kirkpatrick-Baez (KB) mirror is a reflective focusing device that sequentially positions a
pair of crossed mirrors in a grazing-incidence setup. Typically, this type of device offers a …