Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities.
Here, new markers associated with platinum-tolerant cells and tumors were identified using …

During canonical Wnt signalling, the activity of nuclear β‐catenin is largely mediated by the
TCF/LEF family of transcription factors. To challenge this view, we used the CRISPR/Cas9 …

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death
worldwide. HCC can be cured by radical therapies if early diagnosis is done while the tumor …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …

Emerging evidence suggests that cancer is populated and maintained by tumour-initiating
cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite …

The wingless/int1 (WNT)/F rizzled (FZD) signalling pathway controls numerous cellular
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …

About half of all melanomas harbor a mutation that results in a constitutively active BRAF
kinase mutant (BRAFV600E/K) that can be selectively inhibited by targeted BRAF inhibitors …

The predominant p63 isoform, ΔNp63, is a master regulator of normal epithelial stem cell
(SC) maintenance. However, in vivo evidence of the regulation of cancer stem cell (CSC) …