Iodine deficiency
MB Zimmermann - Endocrine reviews, 2009 - academic.oup.com
Iodine deficiency has multiple adverse effects in humans, termed iodine deficiency
disorders, due to inadequate thyroid hormone production. Globally, it is estimated that 2 …
disorders, due to inadequate thyroid hormone production. Globally, it is estimated that 2 …
The sodium/iodide symporter (NIS): molecular physiology and preclinical and clinical applications
S Ravera, A Reyna-Neyra, G Ferrandino… - Annual review of …, 2017 - annualreviews.org
Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …
Thyroid hormone biosynthesis and release
DP Carvalho, C Dupuy - Molecular and cellular endocrinology, 2017 - Elsevier
Abstract Thyroid hormones (TH) 3, 5, 3′, 5'-tetraiodothyronine or thyroxine (T4) and 3, 5, 3'-
triiodothyronine (T3) contain iodine atoms as part of their structure, and their synthesis occur …
triiodothyronine (T3) contain iodine atoms as part of their structure, and their synthesis occur …
The Na+/I− Symporter (NIS): Mechanism and Medical Impact
C Portulano, M Paroder-Belenitsky… - Endocrine …, 2014 - academic.oup.com
Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …
The sodium/iodide symporter (NIS): characterization, regulation, and medical significance
Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …
The sodium/glucose cotransport family SLC5
EM Wright, E Turk - Pflügers Archiv, 2004 - Springer
The sodium/glucose cotransporter family (SLCA5) has 220 or more members in animal and
bacterial cells. There are 11 human genes expressed in tissues ranging from epithelia to the …
bacterial cells. There are 11 human genes expressed in tissues ranging from epithelia to the …
Glucose transport families SLC5 and SLC50
EM Wright - Molecular aspects of medicine, 2013 - Elsevier
There are three families of glucose transporters in the human genome, SLC2, SLC5 and
SLC50. Here I review the structure and function of the SLC5 and SLC50 genes. The human …
SLC50. Here I review the structure and function of the SLC5 and SLC50 genes. The human …
Genetics of congenital hypothyroidism
SM Park, VKK Chatterjee - Journal of medical genetics, 2005 - jmg.bmj.com
Congenital hypothyroidism is the most common neonatal metabolic disorder and results in
severe neurodevelopmental impairment and infertility if untreated. Congenital …
severe neurodevelopmental impairment and infertility if untreated. Congenital …
Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies
M Nishimura, S Naito - Drug metabolism and pharmacokinetics, 2005 - jstage.jst.go.jp
Pairs of forward and reverse primers and TaqMan probes speciˆc to each of 46 human ATP-
binding cassette (ABC) transporters and 108 human solute carrier (SLC) transporters were …
binding cassette (ABC) transporters and 108 human solute carrier (SLC) transporters were …
Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology
A De La Vieja, O Dohan, O Levy… - Physiological …, 2000 - journals.physiology.org
The Na+/I− symporter (NIS) is an intrinsic membrane protein that mediates the active
transport of iodide into the thyroid and other tissues, such as salivary glands, gastric …
transport of iodide into the thyroid and other tissues, such as salivary glands, gastric …