We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Infertility is a prevalent condition affecting an estimated 70 million people globally. The
World Health Organization estimates that 9% of couples worldwide struggle with fertility …

It is estimated that infertility affects 8–12% of couples globally, with a male factor being a
primary or contributing cause in approximately 50% of couples. Causes of male subfertility …

Background The sperm DNA fragmentation index (DFI) is widely regarded as a key measure
for assessing male fertility, but the predictive value of the DFI for outcomes of assisted …

Assessments of sperm DNA damage are controversial because of perceived uncertainties
over the relationship with pregnancy and the limited range of therapies available should …

Objective To summarise the latest evidence on the role of sperm DNA fragmentation (SDF)
in male factor infertility, as SDF has been emerging as a valuable tool for male infertility …

Background Sperm chromatin integrity is essential for normal embryo development and
pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to …

Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is
considered the cornerstone of laboratory evaluation of male infertility, but it has its own …

Varicocele, the leading cause of male infertility, can impair sperm quality and fertility via
various oxidative stress mechanisms. An imbalance between excessive reactive oxygen …