Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer …

Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver
cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC …

Hepatitis C virus (HCV) is one of the major aetiologic agents that causes hepatocellular
carcinoma (HCC) by generating an inflammatory, fibrogenic, and carcinogenic tissue …

Hepatocellular carcinoma (HCC) is the fifth most common cancer, but the third leading
cause of cancer death, in the world, with more than 500 000 fatalities annually. The major …

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading
cause of cancer death worldwide. Despite recent advances in the diagnosis and treatment of …

The non-structural 5A (NS5A) protein of hepatitis C virus (HCV) has been the subject of
intensive research over the last decade. It is generally accepted that NS5A is a pleiotropic …

Hepatitis C virus (HCV) is a major leading cause of hepatocellular carcinoma (HCC). HCV-
induced hepatocarcinogenesis is a multistep process resulting from a combination of …

The nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) has been shown to
interact with a variety of cellular proteins and implicated in the regulation of cell growth …

Some direct-acting antiviral agents for hepatitis C virus (HCV), such as telaprevir and
boceprevir have been available since 2011. It was reported that HCV NS5A is associated …

Interferons (IFNs) induce an antiviral state in the cell through complex and indirect
mechanisms, which culminate in a direct inhibition of viral replication and stimulation of the …