[HTML][HTML] Pyroptosis: A new frontier in cancer
Y Fang, S Tian, Y Pan, W Li, Q Wang, Y Tang… - Biomedicine & …, 2020 - Elsevier
Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …
[HTML][HTML] Potential therapeutic use of the rosemary diterpene carnosic acid for Alzheimer's disease, Parkinson's disease, and long-COVID through NRF2 activation to …
Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory
repute, is employed in traditional medicines in many countries. Rosemary contains carnosic …
repute, is employed in traditional medicines in many countries. Rosemary contains carnosic …
[HTML][HTML] LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138 …
Q Mao, XL Liang, CL Zhang, YH Pang… - Stem cell research & …, 2019 - Springer
Aim Myocardial infarction (MI) is a severe disease with increased mortality and disability
rates, posing heavy economic burden for society. Exosomes were uncovered to mediate …
rates, posing heavy economic burden for society. Exosomes were uncovered to mediate …
[HTML][HTML] The NLRP1 inflammasome in human skin and beyond
G Fenini, T Karakaya, P Hennig, M Di Filippo… - International journal of …, 2020 - mdpi.com
Inflammasomes represent a group of protein complexes that contribute to host defense
against pathogens and repair processes upon the induction of inflammation. However …
against pathogens and repair processes upon the induction of inflammation. However …
[HTML][HTML] Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo
W Liu, Y Chen, J Meng, M Wu, F Bi, C Chang… - Journal of …, 2018 - Springer
Background Traumatic brain injury (TBI) is a critical public health and socioeconomic
problem throughout the world. Inflammation-induced secondary injury is one of the vital …
problem throughout the world. Inflammation-induced secondary injury is one of the vital …
[HTML][HTML] Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling
Y Li, Q Jiang - Frontiers in Immunology, 2023 - frontiersin.org
Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …
associated molecular patterns and pathogen-associated molecular patterns. Upon …
[HTML][HTML] Inflammasome and autophagy regulation: a two-way street
Inflammation plays a significant role in protecting hosts against pathogens. Inflammation
induced by noninfectious endogenous agents can be detrimental and, if excessive, can …
induced by noninfectious endogenous agents can be detrimental and, if excessive, can …
In vivo visualization of tumor-associated macrophages re-education by photoacoustic/fluorescence dual-modal imaging with a metal-organic frames-based caspase-1 …
Tumor-associated macrophages (TAMs) are vital in the tumor microenvironment,
contributing to immunosuppression and therapy tolerance. Despite their importance, the …
contributing to immunosuppression and therapy tolerance. Despite their importance, the …
A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer
PA Vieyra-Garcia, P Wolf - Pharmacology & therapeutics, 2021 - Elsevier
UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …
successful history in the management of numerous cutaneous disorders. Photoresponsive …
[HTML][HTML] Inflammasome contribution to the activation of Th1, Th2, and Th17 immune responses
E Martynova, A Rizvanov, RA Urbanowicz… - Frontiers in …, 2022 - frontiersin.org
Inflammasomes are cytosolic polyprotein complexes formed in response to various external
and internal stimuli, including viral and bacterial antigens. The main product of the …
and internal stimuli, including viral and bacterial antigens. The main product of the …