Discovering multifaceted role of vanillic acid beyond flavours: Nutraceutical and therapeutic potential

J Kaur, M Gulati, SK Singh, G Kuppusamy… - Trends in Food Science …, 2022 - Elsevier
Background Vanillic acid is a phenolic compound, found in various dietary sources and
medicinal plants. Apart from its extraction from these biological sources, it is also …

[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

CL Wainwright, MM Teixeira, DL Adelson… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

[HTML][HTML] Plant constituents and thyroid: A revision of the main phytochemicals that interfere with thyroid function

G Di Dalmazi, C Giuliani - Food and Chemical Toxicology, 2021 - Elsevier
In the past few decades, there has been a lot of interest in plant constituents for their
antioxidant, anti-inflammatory, anti-microbial and anti-proliferative properties. However …

[HTML][HTML] Identification and characterization of phytochemicals and constituents in Desmodium velutinum stem using high-performance liquid chromatography (HPLC)

CC Nkwocha, MO Ogugofor, IF Chukwuma… - Pharmacological …, 2022 - Elsevier
The aim of this study was to analyse and identify phytochemicals and bioactive constituents
present in Desmodium velutinum stem. Fresh stems of Desmodium velutinum were air-dried …

Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases

Q Lu, Y Tang, S Luo, Q Gong, C Li - The American Journal of …, 2023 - World Scientific
Naturally derived alkaloids belong to a class of quite significant organic compounds.
Coptisine, a benzyl tetrahydroisoquinoline alkaloid, is one of the major bioactive …

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

G Di Dalmazi, C Giuliani, I Bucci, M Mascitti… - International Journal of …, 2024 - mdpi.com
Thyroid cancer (TC) and thyroid autoimmune disorders (AITD) are among the most common
diseases in the general population, with higher incidence in women. Chronic inflammation …

Structure‐based study to identify alkaloids as promising cytochrome P450 (CYP1A1) inhibitors: An in silico approach using virtual screening, molecular dynamic …

VV Verma, L Bhargava, M Sajid… - Journal of Cellular …, 2022 - Wiley Online Library
Carcinogens present in smokeless tobacco (SLT) like tobacco‐specific nitrosamines can be
metabolized by the cytochrome P450 (CYP450) enzyme. Functionally, the CYP450 enzyme …

The Effect of Natural Plant Products in the Management of Autoimmune Diseases Along with Photodynamic Therapy

C Özay, B Sirek, E Bakay, N Topaloğlu - Revista Brasileira de …, 2024 - Springer
Due to the high prevalence and inefficiency of the already existing treatment of autoimmune
diseases, researchers are investigating new treatment modalities for these diseases. One of …

Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B …

L Huang, X Zhong, Z Zhou, Y Cai, M Deng - Applied Biological Chemistry, 2022 - Springer
Piperine, the major pharmacological ingredient of pepper, can delay the procession of
neuropharmacological effects, but its effects and mechanisms on Parkinson's disease …

TULP3 NLS inhibition: an in silico study to hamper cargo transport to nucleus

RM Mateen, A Tariq, MS Afzal, M Ali, I Tipu… - Journal of …, 2023 - Taylor & Francis
TULP3 is involved in cell regulation pathways including transcription and signal
transduction. In some pathological states like in cancers, increased level of TULP3 has been …