Epigenetic regulatory layers in the 3D nucleus
Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …
Neurobiological functions of transcriptional enhancers
AS Nord, AE West - Nature Neuroscience, 2020 - nature.com
Transcriptional enhancers are regulatory DNA elements that underlie the specificity and
dynamic patterns of gene expression. Over the past decade, large-scale functional …
dynamic patterns of gene expression. Over the past decade, large-scale functional …
[HTML][HTML] Cell-type specialization is encoded by specific chromatin topologies
W Winick-Ng, A Kukalev, I Harabula, L Zea-Redondo… - Nature, 2021 - nature.com
Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …
gene regulation and cell function,–. Methods based on chromatin conformation capture have …
The possible role of brain-derived neurotrophic factor in epilepsy
R AlRuwaili, HM Al-Kuraishy, AI Al-Gareeb… - Neurochemical …, 2024 - Springer
Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …
[HTML][HTML] Therapeutic role of growth factors in treating diabetic wound
Wounds in diabetic patients, especially diabetic foot ulcers, are more difficult to heal
compared with normal wounds and can easily deteriorate, leading to amputation. Common …
compared with normal wounds and can easily deteriorate, leading to amputation. Common …
The neuronal activity-driven transcriptome
E Benito, A Barco - Molecular Neurobiology, 2015 - Springer
Activity-driven transcription is a key event associated with long-lasting forms of neuronal
plasticity. Despite the efforts to investigate the regulatory mechanisms that control this …
plasticity. Despite the efforts to investigate the regulatory mechanisms that control this …
Chromatin regulation of neuronal maturation and plasticity
DA Gallegos, U Chan, LF Chen, AE West - Trends in neurosciences, 2018 - cell.com
Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …
MeCP2: a critical regulator of chromatin in neurodevelopment and adult brain function
Methyl CpG binding protein 2 (MeCP2) was first identified as a nuclear protein with a
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …
Understanding the 3D genome: emerging impacts on human disease
A Krumm, Z Duan - Seminars in cell & developmental biology, 2019 - Elsevier
Recent burst of new technologies that allow for quantitatively delineating chromatin structure
has greatly expanded our understanding of how the genome is organized in the three …
has greatly expanded our understanding of how the genome is organized in the three …
[HTML][HTML] High-resolution spatial multi-omics reveals cell-type specific nuclear compartments
The mammalian nucleus is compartmentalized by diverse subnuclear structures. These
subnuclear structures, marked by nuclear bodies and histone modifications, are often cell …
subnuclear structures, marked by nuclear bodies and histone modifications, are often cell …