Chronic hepatitis B virus (HBV) infection remains a global problem. Several HBV genotypes
exist with different biology and geographical prevalence. Whilst the future aim of HBV …

The clinical course of infections with the hepatitis B virus (HBV) substantially varies between
individuals, as a consequence of a complex interplay between viral, host, environmental and …

Abstract The UniProt Knowledgebase is a collection of sequences and annotations for over
120 million proteins across all branches of life. Detailed annotations extracted from the …

Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …

Background & Aims It has been proposed that serum hepatitis B core-related antigen
(HBcrAg) reflects intrahepatic covalently closed circular (ccc) DNA levels. However, the …

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) system has revolutionized biomedical research and facilitated the …

Viruses represent the most abundant life forms on the planet. Recent experimental and
computational improvements have led to a dramatic increase in the number of viral genome …

Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment
approaches are needed because current treatments do not target covalently closed circular …

ABSTRACT Background & Aims The WHO declared to eliminate hepatitis B virus (HBV) by
2030. However, an increasing number of patients are presenting with low-level viremia …

Background & Aims Hepatitis B virus (HBV) persistence and the pathobiology of chronic
HBV (CHB) infections result from the interplay between viral replication and host immune …