The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important
element of the ubiquitin system. Together with a network of cofactors, it regulates an ever …

The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in
ubiquitin-dependent protein quality control and intracellular signalling pathways. It …

How are biological structures maintained in a cellular environment that constantly threatens
protein integrity? Here we elucidate proteostasis mechanisms affecting the Z disk, a protein …

Loss of myofibrillar proteins is a hallmark of atrophying muscle. Expression of muscle RING-
finger 1 (MuRF1), a ubiquitin ligase, is markedly induced during atrophy, and MuRF1 …

Mutations in valosin-containing protein (VCP) cause inclusion body myopathy (IBM), Paget's
disease of the bone, and frontotemporal dementia (IBMPFD). Patient muscle has …

A specific small-molecule inhibitor of p97 would provide an important tool to investigate
diverse functions of this essential ATPase associated with diverse cellular activities (AAA) …

Mutations in VCP cause multisystem degeneration impacting the nervous system, muscle,
and/or bone. Patients may present with ALS, Parkinsonism, frontotemporal dementia …

Abstract The AAA-ATPase VCP (also known as p97) cooperates with distinct cofactors to
process ubiquitylated proteins in different cellular pathways,,. VCP missense mutations …

The accumulation of the human tumor suppressor 53BP1 at DNA damage sites requires the
ubiquitin ligases RNF8 and RNF168. As 53BP1 recognizes dimethylated Lys20 in histone …

Summary p97 is an ATP-dependent chaperone that plays an important role in endoplasmic
reticulum-associated degradation but whose connections to turnover of soluble proteins …