For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

Inductively coupled plasma mass spectrometry (ICP-MS) combines plasma chemistry, which
produces singly charged elemental ions, with mass spectrometric detection. Unlike other …

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but
neurons do not work in isolation. Emerging evidence suggests that the intricate balance of …

Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …

Mass cytometry has revolutionized immunophenotyping, particularly in exploratory settings
where simultaneous breadth and depth of characterization of immune populations is needed …

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …

Amyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disorder that
affects motor neurons and voluntary muscle control. ALS heterogeneity includes the age of …

As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

Abstract Characterization of immune responses is currently hampered by the lack of systems
enabling quantitative and dynamic phenotypic characterization of individual cells and, in …

Multiple effector layers in the immune system ensure an optimal temporal and spatial
distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive …