Advances in COVID-19 mRNA vaccine development

E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

The dawn of mRNA vaccines: The COVID-19 case

R Verbeke, I Lentacker, SC De Smedt… - Journal of Controlled …, 2021 - Elsevier
In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based
vaccines, BNT162b2 and mRNA-1273, were granted the first historic authorization for …

mRNA vaccines in the COVID-19 pandemic and beyond

MJ Hogan, N Pardi - Annual review of medicine, 2022 - annualreviews.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus
disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around …

Nanomaterial delivery systems for mRNA vaccines

MD Buschmann, MJ Carrasco, S Alishetty, M Paige… - Vaccines, 2021 - mdpi.com
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …

Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

K Bok, S Sitar, BS Graham, JR Mascola - Immunity, 2021 - cell.com
The development of effective vaccines to combat infectious diseases is a complex multi-year
and multi-stakeholder process. To accelerate the development of vaccines for coronavirus …

COVID-19 mRNA vaccines: Platforms and current developments

GT Szabó, AJ Mahiny, I Vlatkovic - Molecular Therapy, 2022 - cell.com
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …

Challenges of storage and stability of mRNA-based COVID-19 vaccines

MN Uddin, MA Roni - Vaccines, 2021 - mdpi.com
In December 2019, a new and highly pathogenic coronavirus emerged—coronavirus
disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome …

Covid‐19 vaccines and variants of concern: a review

I Hadj Hassine - Reviews in medical virology, 2022 - Wiley Online Library
Since the outbreak of coronavirus disease 2019 (Covid‐19) in December 2019, caused by
the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the number of …

Nanodelivery of nucleic acids

BB Mendes, J Conniot, A Avital, D Yao… - Nature reviews …, 2022 - nature.com
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

Nucleic acid delivery for therapeutic applications

A Gupta, JL Andresen, RS Manan, R Langer - Advanced Drug Delivery …, 2021 - Elsevier
Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …