PD-L1 as a biomarker of response to immune-checkpoint inhibitors

DB Doroshow, S Bhalla, MB Beasley… - Nature reviews Clinical …, 2021 - nature.com
Immune-checkpoint inhibitors targeting PD-1 or PD-L1 have already substantially improved
the outcomes of patients with many types of cancer, although only 20–40% of patients derive …

[HTML][HTML] Immunohistochemistry for predictive biomarkers in non-small cell lung cancer

M Mino-Kenudson - Translational Lung Cancer Research, 2017 - ncbi.nlm.nih.gov
In the era of targeted therapy, predictive biomarker testing has become increasingly
important for non-small cell lung cancer. Of multiple predictive biomarker testing methods …

[HTML][HTML] Concordance study of PD-L1 expression in primary and metastatic bladder carcinomas: comparison of four commonly used antibodies and RNA expression

M Tretiakova, R Fulton, M Kocherginsky, T Long… - Modern Pathology, 2018 - Elsevier
Therapy with anti-PD-L1 immune check-point inhibitors is approved for several cancers,
including advanced urothelial carcinomas. PD-L1 prevalence estimates vary widely in …

PD-L1 immunohistochemistry assay concordance in urothelial carcinoma of the bladder and hypopharyngeal squamous cell carcinoma

A Hodgson, E Slodkowska, A Jungbluth… - The American journal …, 2018 - journals.lww.com
Abstract Programmed death ligand-1 (PD-L1) immunohistochemistry is used to guide
treatment decisions regarding the use of checkpoint immunotherapy in the management of …

[HTML][HTML] Prevalence and heterogeneity of PD-L1 expression by 22C3 assay in routine population-based and reflexive clinical testing in lung cancer

DM Hwang, T Albaqer, RC Santiago, J Weiss… - Journal of Thoracic …, 2021 - Elsevier
Introduction Programmed death-ligand 1 (PD-L1) is used as a biomarker for anti–
programmed cell death protein-1 (PD-1) or anti-PD-L1 immunotherapies in NSCLC. We …

PD-L1 expression combined with microsatellite instability/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

T Morihiro, S Kuroda, N Kanaya, Y Kakiuchi… - Scientific reports, 2019 - nature.com
While the importance of programmed death-ligand 1 (PD-L1), mutation burden caused by
microsatellite instability (MSI), and CD8+ tumor infiltrating lymphocytes (TILs) has become …

Comparability of PD‐L1 immunohistochemistry assays for non‐small‐cell lung cancer: a systematic review

BM Koomen, SK Badrising, MM van den Heuvel… - …, 2020 - Wiley Online Library
Programmed cell death ligand 1 (PD‐L1) immunohistochemistry is used to determine which
patients with advanced non‐small‐cell lung cancer (NSCLC) respond best to treatment with …

Analysis of Expression of Programmed Cell Death Ligand 1 (PD-L1) and BRAFV600E Mutation in Thyroid Cancer

M Sekino, M Iwadate, Y Yamaya, Y Matsumoto… - Cancers, 2023 - mdpi.com
Simple Summary Immune checkpoint inhibitors are expected to be used in clinical practice
to treat thyroid cancer. Programmed cell death ligand 1 (PD-L1) is the ligand expressed on …

Programmed Death Ligand-1 and Tumor Mutation Burden Testing of Patients With Lung Cancer for Selection of Immune Checkpoint Inhibitor Therapies: Guideline …

LM Sholl, M Awad, U Basu Roy… - … of Pathology & …, 2024 - meridian.allenpress.com
Context.—Rapid advancements in the understanding and manipulation of tumor-immune
interactions have led to the approval of immune therapies for patients with non–small cell …

Programmed cell death ligand‐1 protein expression and CD274/PD‐L1 gene amplification in colorectal cancer: Implications for prognosis

KS Lee, BH Kim, HK Oh, DW Kim, SB Kang… - Cancer …, 2018 - Wiley Online Library
Programmed cell death ligand‐1 (PD‐L1) detection assays have not been standardized for
patients with colorectal cancer, and the prognostic value of PD‐L1 expression is unclear. We …