Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …

With the integration of nanotechnology into the medical field at large, great strides have
been made in the development of nanomedicines for tackling different diseases, including …

The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections
and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune …

Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the
origins and functions of distinct CAF subtypes remain poorly understood. The abundant and …

INTRODUCTION The remarkable development of a single cell, the zygote, into the full
organism occurs through a complex series of division and differentiation events that …

The CRISPR/Cas9 system enables genome editing and somatic cell genetic screens in
mammalian cells. We performed genome-scale loss-of-function screens in 33 cancer cell …

Genetically engineered mouse models (GEMM s) have contributed significantly to the field of
cancer research. In contrast to cancer cell inoculation models, GEMM s develop de novo …

Immunosurveillance of cancer requires the presentation of peptide antigens on major
histocompatibility complex class I (MHC-I) molecules,,,–. Current approaches to profiling of …

Background Therapy for glioblastoma (GBM) has always been very challenging, not only
because of the presence of the blood-brain barrier (BBB) but also due to susceptibility to …