Endogenous opiates and behavior: 2022

RJ Bodnar - Peptides, 2023 - Elsevier
This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The Impact of P-Glycoprotein on Opioid Analgesics: What's the Real Meaning in Pain Management and Palliative Care?

F Coluzzi, MS Scerpa, M Rocco… - International Journal of …, 2022 - mdpi.com
Opioids are widely used in cancer and non-cancer pain management. However, many
transporters at the blood–brain barrier (BBB), such as P-glycoprotein (P-gp, ABCB1/MDR1) …

Central Nervous System Delivery and Pharmacokinetics of Novel Therapeutics: Implications for Combinations of Small Molecules and Antibody-Drug Conjugates

JIG Griffith - 2022 - search.proquest.com
The central nervous system (CNS) barriers, in particular the blood-brain barrier (BBB), play a
critical role in the delivery, safety, and efficacy of drugs. The BBB prevents the distribution of …

[PDF][PDF] Laxative Potential of Ethanol Leaf Extract of Securinega virosa in Loperamide Induced Constipated Wistar Rats

SM Obidola, A Olatunde, UU Henry… - Nigerian Journal of …, 2022 - researchgate.net
Constipation is the inability of individuals to empty the bowel for a period of three times a
week which causes discomfort and even sometimes lead to colorectal cancer. This work was …