Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …

Multidrug resistance (MDR) has appeared in response to selective pressures resulting from
the incorrect use of antibiotics and other antimicrobials. This inappropriate application and …

Highlights•Structure-based mechanisms are available for five major classes of multi-drug
transporters.•Three transporter classes form tripartite assemblies spanning the bacterial cell …

The emergence of drug resistance continues to plague TB control, with a global increase in
the prevalence of MDR-TB. This acts as a gateway to XDR-TB and thus emphasizes the …

Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

The biology of mycobacteria is dominated by a complex cell envelope of unique composition
and structure and of exceptionally low permeability. This cell envelope is the basis of many …

Drug tolerance likely represents an important barrier to tuberculosis treatment shortening.
We previously implicated the Mycobacterium tuberculosis efflux pump Rv1258c as …

Drug-resistant tuberculosis (TB) is one of the most lethal diseases, and it is imperative to
exploit an advanced drug formulation for its effective treatment. This work aims to develop a …