[HTML][HTML] Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities
Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …
[HTML][HTML] A review of the effect of exosomes from different cells on liver fibrosis
X Hu, Q Ge, Y Zhang, B Li, E Cheng, Y Wang… - Biomedicine & …, 2023 - Elsevier
Hepatic fibrosis (HF) is a common pathological process caused by various acute and
chronic liver injury factors, which is mainly characterized by inflammation and excessive …
chronic liver injury factors, which is mainly characterized by inflammation and excessive …
[HTML][HTML] The SLIT/ROBO pathway in liver fibrosis and cancer
Liver fibrosis is a common outcome of most chronic liver insults/injuries that can develop into
an irreversible process of cirrhosis and, eventually, liver cancer. In recent years, there has …
an irreversible process of cirrhosis and, eventually, liver cancer. In recent years, there has …
Discovery and design of novel cyclic peptides as specific inhibitors targeting CCN2 and disrupting CCN2/EGFR interaction for kidney fibrosis treatment
J Dong, J Xiao, J Li, H Yu, Q Zhao, Q Tang… - Journal of Medicinal …, 2023 - ACS Publications
Kidney fibrosis is a serious consequence of chronic kidney disease (CKD), and currently,
there is no effective pharmacological treatment available. Cellular communication network-2 …
there is no effective pharmacological treatment available. Cellular communication network-2 …
Identification and Characterization of a Novel Nanobody Against Human CTGF to Reveal Its Antifibrotic Effect in an in vitro Model of Liver Fibrosis
R Liu, M Zhu, J Chen, J Gai, J Huang… - International Journal …, 2023 - Taylor & Francis
Background No agents are currently available for the treatment or reversal of liver fibrosis.
Novel antifibrotic therapies for chronic liver diseases are thus urgently needed. Connective …
Novel antifibrotic therapies for chronic liver diseases are thus urgently needed. Connective …
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets
V Xega, T Alami, JL Liu - Journal of Cell Communication and Signaling, 2023 - Springer
CCN/WISP (cellular communication network factors, or Wnt-inducted secreted proteins)
family of proteins consists of six extracellular matrix (ECM)-associated proteins that regulate …
family of proteins consists of six extracellular matrix (ECM)-associated proteins that regulate …
Axon guidance genes control hepatic artery development
L Gannoun, C De Schrevel, M Belle… - …, 2023 - journals.biologists.com
Earlier data on liver development demonstrated that morphogenesis of the bile duct, portal
mesenchyme and hepatic artery is interdependent, yet how this interdependency is …
mesenchyme and hepatic artery is interdependent, yet how this interdependency is …
[HTML][HTML] Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells
E Borkham-Kamphorst, SK Meurer… - Journal of Cell …, 2023 - Springer
The cellular (centralized) communication network (CCN) factor protein family contains six
small secreted cysteine-rich proteins sharing high structural similarity. These matricellular …
small secreted cysteine-rich proteins sharing high structural similarity. These matricellular …
Significance of CCNs in liver regeneration
JM Barkin, B Jin-Smith, K Torok, L Pi - Journal of Cell Communication and …, 2023 - Springer
The liver has an inherent regenerative capacity via hepatocyte proliferation after mild-to-
modest damage. When hepatocytes exhaust their replicative ability during chronic or severe …
modest damage. When hepatocytes exhaust their replicative ability during chronic or severe …
Connective Tissue Growth Factor: Regulation, Diseases, and Drug Discovery
M Ren, S Yao, T Chen, H Luo, X Tao, H Jiang… - International Journal of …, 2024 - mdpi.com
In drug discovery, selecting targeted molecules is crucial as the target could directly affect
drug efficacy and the treatment outcomes. As a member of the CCN family, CTGF (also …
drug efficacy and the treatment outcomes. As a member of the CCN family, CTGF (also …