m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression

J Chen, K Li, J Chen, X Wang, R Ling… - Cancer …, 2022 - Wiley Online Library
Background Cancer cells selectively promote the translation of oncogenic transcripts to
stimulate cancer progression. Although growing evidence has revealed that tRNA …

N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma

B Chen, W Jiang, Y Huang, J Zhang, P Yu, L Wu… - Oncogene, 2022 - nature.com
Abstract Treatment selections are very limited for patients with advanced nasopharyngeal
carcinoma (NPC) experiencing disease progression. Uncovering mechanisms underlying …

METTL3 restrains papillary thyroid cancer progression via m6A/c-Rel/IL-8-mediated neutrophil infiltration

J He, M Zhou, J Yin, J Wan, J Chu, J Jia, J Sheng… - Molecular Therapy, 2021 - cell.com
Growing evidence indicates that N6-methyladenosine (m 6 A) is the most pervasive RNA
modification in eukaryotic cells. However, the specific role of METTL3 in papillary thyroid …

[HTML][HTML] The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer

CY Sun, D Cao, BB Du, CW Chen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …

N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma

F Wang, Y Liao, M Zhang, Y Zhu, W Wang, H Cai… - Oncogene, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant internal mRNA modification in
eukaryotes and plays an important role in tumorigenesis. However, the underlying …

m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency

G Li, R Luo, W Zhang, S He, B Wang… - Clinical and …, 2022 - Wiley Online Library
Background The intervertebral disc (IVD) degeneration is the leading cause of low back
pain, which accounts for a main cause of disability. N6‐methyladenosine (m6A) is the most …

Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis

Y Li, Y Zhang, T Zhang, X Ping, D Wang… - Advanced …, 2023 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) modification has been implicated in the progression of
obesity and metabolic diseases. However, its impact on beige fat biology is not well …

METTL3-mediated m6A mRNA modification promotes esophageal cancer initiation and progression via Notch signaling pathway

H Han, C Yang, S Zhang, M Cheng, S Guo… - … Therapy-Nucleic Acids, 2021 - cell.com
Esophageal cancer is a lethal malignancy with a high mortality rate, while the molecular
mechanisms underlying esophageal cancer pathogenesis are still poorly understood. Here …