The application of biocatalysis in conquering challenging synthesis requires the constant
input of new enzymes. Developing novel biocatalysts by absorbing catalysis modes from …

Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …

Many enzymes work in tandem with small molecule cofactors, which have inspired
organocatalyst designs. Chemical modification of cofactor scaffolds has increased …

Enantioselective C–H amidation offers attractive means to assemble C–N bonds to
synthesize high-added value, nitrogen-containing molecules. In recent decades …

Here we report a practical, highly enantioselective photoredox allylation of aldehydes
mediated by chiral nickel complexes with commercially available allyl acetate as the …

Consistent introduction of novel enzymes is required for developing efficient biocatalysts for
challenging biotransformations. Absorbing catalytic modes from organocatalysis may be …

Catalytic transfer hydrogenation reactions (CTHs) produce value-added chemicals in the
most economical, safe, green, and sustainable way. However, understanding the reaction …

The combination of chemo-and biocatalysis for multistep syntheses provides attractive
advantages in terms of evolvability, promiscuity, and sustainability striving for desirable …

Secondary amines, due to their reactivity, can transform protein templates into catalytically
active entities, accelerating the development of artificial enzymes. However, existing …

Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions.
The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal …