Unlocking new reactivities in enzymes by iminium catalysis
G Xu, GJ Poelarends - Angewandte Chemie International …, 2022 - Wiley Online Library
The application of biocatalysis in conquering challenging synthesis requires the constant
input of new enzymes. Developing novel biocatalysts by absorbing catalysis modes from …
input of new enzymes. Developing novel biocatalysts by absorbing catalysis modes from …
Multifunctional biocatalyst for conjugate reduction and reductive amination
TW Thorpe, JR Marshall, V Harawa, RE Ruscoe… - Nature, 2022 - nature.com
Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …
Going full circle with organocatalysis and biocatalysis: the latent potential of cofactor mimics in asymmetric synthesis
J Murray, DRW Hodgson… - The Journal of Organic …, 2023 - ACS Publications
Many enzymes work in tandem with small molecule cofactors, which have inspired
organocatalyst designs. Chemical modification of cofactor scaffolds has increased …
organocatalyst designs. Chemical modification of cofactor scaffolds has increased …
Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated C(sp3)–H Bonds
K Yu, Z Zou, NV Igareta, R Tachibana… - Journal of the …, 2023 - ACS Publications
Enantioselective C–H amidation offers attractive means to assemble C–N bonds to
synthesize high-added value, nitrogen-containing molecules. In recent decades …
synthesize high-added value, nitrogen-containing molecules. In recent decades …
Nickel‐Mediated Enantioselective Photoredox Allylation of Aldehydes with Visible Light
Here we report a practical, highly enantioselective photoredox allylation of aldehydes
mediated by chiral nickel complexes with commercially available allyl acetate as the …
mediated by chiral nickel complexes with commercially available allyl acetate as the …
Design and Evolution of an Enzyme for the Asymmetric Michael Addition of Cyclic Ketones to Nitroolefins by Enamine Catalysis
Z Zhu, Q Hu, Y Fu, Y Tong… - Angewandte Chemie …, 2024 - Wiley Online Library
Consistent introduction of novel enzymes is required for developing efficient biocatalysts for
challenging biotransformations. Absorbing catalytic modes from organocatalysis may be …
challenging biotransformations. Absorbing catalytic modes from organocatalysis may be …
[HTML][HTML] The inorganic perovskite-catalyzed transfer hydrogenation of cinnamaldehyde using glycerol as a hydrogen donor
Catalytic transfer hydrogenation reactions (CTHs) produce value-added chemicals in the
most economical, safe, green, and sustainable way. However, understanding the reaction …
most economical, safe, green, and sustainable way. However, understanding the reaction …
Binding of Dual-Function Hybridized Metal–Organic Capsules to Enzymes for Cascade Catalysis
J Cai, L Zhao, Y Li, C He, C Wang, C Duan - JACS Au, 2022 - ACS Publications
The combination of chemo-and biocatalysis for multistep syntheses provides attractive
advantages in terms of evolvability, promiscuity, and sustainability striving for desirable …
advantages in terms of evolvability, promiscuity, and sustainability striving for desirable …
Secondary amine catalysis in enzyme design: broadening protein template diversity through genetic code expansion
TL Williams, IM Taily, L Hatton, AA Berezin… - Angewandte …, 2024 - Wiley Online Library
Secondary amines, due to their reactivity, can transform protein templates into catalytically
active entities, accelerating the development of artificial enzymes. However, existing …
active entities, accelerating the development of artificial enzymes. However, existing …
Derivatives of natural organocatalytic cofactors and artificial organocatalytic cofactors as catalysts in enzymes
H Lechner, G Oberdorfer - ChemBioChem, 2022 - Wiley Online Library
Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions.
The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal …
The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal …