The SARS-CoV-2 nucleocapsid protein and its role in viral structure, biological functions, and a potential target for drug or vaccine mitigation

Z Bai, Y Cao, W Liu, J Li - Viruses, 2021 - mdpi.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world
is still expanding. Thus, there is an urgent need to better understand this novel virus and find …

mRNA vaccines in the prevention and treatment of diseases

Y Gu, J Duan, N Yang, Y Yang, X Zhao - MedComm, 2022 - Wiley Online Library
Messenger ribonucleic acid (mRNA) vaccines made their successful public debut in the
effort against the COVID‐19 outbreak starting in late 2019, although the history of mRNA …

B and T cell response to SARS-CoV-2 vaccination in health care professionals with and without previous COVID-19

A Zollner, C Watschinger, A Rössler, MR Farcet… - …, 2021 - thelancet.com
Background In recent months numerous health care professional acquired COVID-19 at the
workplace resulting in significant shortages in medical and nursing staff. We investigated …

Nucleocapsid protein of SARS‐CoV‐2 is a potential target for developing new generation of vaccine

W Feng, Y Xiang, L Wu, Z Chen, Q Li… - Journal of Clinical …, 2022 - Wiley Online Library
Background SARS‐CoV‐2 has spread worldwide causing more than 400 million people
with virus infections since early 2020. Currently, the existing vaccines targeting the spike …

Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVs

M Thura, JXE Sng, KH Ang, J Li, A Gupta… - Bioscience …, 2021 - portlandpress.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global
pandemic of the Coronavirus disease in late 2019 (COVID-19). Vaccine development efforts …

Immunogenicity and protectivity of the peptide vaccine against SARS-CoV-2

AB Ryzhikov, EА Ryzhikov… - Annals of the …, 2021 - vestnikramn.spr-journal.ru
Background. In 2020, the pandemic caused by novel coronavirus infection has become one
of the most critical global health challenges during the past century. The lack of a vaccine, as …

A universal SARS‐CoV DNA vaccine inducing highly cross‐reactive neutralizing antibodies and T cells

S Appelberg, G Ahlén, J Yan, N Nikouyan… - EMBO Molecular …, 2022 - embopress.org
New variants in the SARS‐CoV‐2 pandemic are more contagious (Alpha/Delta), evade
neutralizing antibodies (Beta), or both (Omicron). This poses a challenge in vaccine …

SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects

J Zhao, L Wang, M Schank, X Dang, Z Lu, D Cao… - Virus Research, 2021 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 infection poses a serious threat to public
health. An explicit investigation of COVID-19 immune responses, particularly the host …

ATP biphasically modulates LLPS of SARS-CoV-2 nucleocapsid protein and specifically binds its RNA-binding domain

M Dang, Y Li, J Song - Biochemical and Biophysical Research …, 2021 - Elsevier
SARS-CoV-2 is a highly contagious coronavirus causing the ongoing pandemic. Very
recently its genomic RNA of∼ 30 kb was decoded to be packaged with nucleocapsid (N) …

Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

A Ghaemi, P Roshani Asl, H Zargaran… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2 has caused a global pandemic, infecting millions of people. An effective
preventive vaccine against this virus is urgently needed. Here, we designed and developed …