Riboflavin derivatives are essential cofactors for a myriad of flavoproteins. In bacteria, flavins
importance extends beyond their role as intracellular protein cofactors, as secreted flavins …

The substrate specificity of enzymes is bound to be imperfect, because of unavoidable
physicochemical limits. In extant metabolic enzymes, furthermore, such limits are seldom …

Small molecules containing the N-nitroso group, such as the bacterial natural product
streptozotocin, are prominent carcinogens, and important cancer chemotherapeutics …

Ticks and other arthropods often are hosts to nutrient providing bacterial endosymbionts,
which contribute to their host's fitness by supplying nutrients such as vitamins and amino …

Promiscuity is the coincidental ability of an enzyme to catalyze its native reaction and
additional reactions that are not biological functions in the same active site. Promiscuity …

Chlamydia protein associating with death domains (CADD) is involved in the biosynthesis of
para-aminobenzoate (pABA), an essential component of the folate cofactor that is required …

BesC catalyzes the iron-and O2-dependent cleavage of 4-chloro-l-lysine to form 4-chloro-l-
allylglycine, formaldehyde, and ammonia. This process is a critical step for a biosynthetic …

In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron
oxygenase SznF hydroxylates N δ and N ω′ of N ω-methyl-l-arginine before oxidatively …

UndA is a nonheme iron enzyme that activates oxygen to catalyze the decarboxylation of
dodecanoic acid to undecene and carbon dioxide. We report the first optical and …

The alkylating warhead of the pancreatic cancer drug streptozotocin (SZN) contains an N-
nitrosourea moiety constructed from N ω-methyl-l-arginine (l-NMA) by the multi-domain …