Pathophysiology and mechanism of long COVID: a comprehensive review

D Castanares-Zapatero, P Chalon, L Kohn… - Annals of …, 2022 - Taylor & Francis
Background After almost 2 years of fighting against SARS-CoV-2 pandemic, the number of
patients enduring persistent symptoms long after acute infection is a matter of concern. This …

COVID-19 and preexisting comorbidities: risks, synergies, and clinical outcomes

B Bigdelou, MR Sepand, S Najafikhoshnoo… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated
symptoms, named coronavirus disease 2019 (COVID-19), have rapidly spread worldwide …

“LONG COVID”—A hypothesis for understanding the biological basis and pharmacological treatment strategy

B Jarrott, R Head, KG Pringle… - Pharmacology …, 2022 - Wiley Online Library
Infection of humans with SARS‐CoV‐2 virus causes a disease known colloquially as
“COVID‐19” with symptoms ranging from asymptomatic to severe pneumonia. Initial …

Migraine and neuroinflammation: the inflammasome perspective

O Kursun, M Yemisci… - The journal of headache …, 2021 - Springer
Background Neuroinflammation has an important role in the pathophysiology of migraine,
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …

The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential …

H Zalpoor, A Akbari, A Samei… - Cellular & Molecular …, 2022 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

N Amruta, WH Chastain, M Paz, RJ Solch… - Cytokine & growth factor …, 2021 - Elsevier
SARS-CoV-2 is a novel coronavirus that severely affects the respiratory system, is the cause
of the COVID-19 pandemic, and is projected to result in the deaths of 2 million people …

Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy

H Kong, H Zhao, T Chen, Y Song, Y Cui - Cell Death & Disease, 2022 - nature.com
Retinal endothelial cells (RECs) are the primary target cells for diabetes-induced vascular
damage. The P2X7/NLRP3 pathway plays an essential role in amplifying inflammation via …

The COVID-19 pandemic and Alzheimer's disease: mutual risks and mechanisms

F Chen, Y Chen, Y Wang, Q Ke, L Cui - Translational neurodegeneration, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

RF Damiano, BF Guedes, CC de Rocca… - European archives of …, 2022 - Springer
Recently, much attention has been drawn to the importance of the impact of infectious
disease on human cognition. Several theories have been proposed, to explain the cognitive …