MITF—the first 25 years
CR Goding, H Arnheiter - Genes & development, 2019 - genesdev.cshlp.org
All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …
The role of enhancers in cancer
Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …
most important functions is the integration of extracellular signals with intracellular cell fate …
Perturbation-response genes reveal signaling footprints in cancer gene expression
M Schubert, B Klinger, M Klünemann, A Sieber… - Nature …, 2018 - nature.com
Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …
research. A common approach is to infer signaling activity of pathways from gene …
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions
Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …
[HTML][HTML] The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology
A Kawakami, DE Fisher - Laboratory investigation, 2017 - Elsevier
Certain transcription factors have vital roles in lineage development, including specification
of cell types and control of differentiation. Microphthalmia-associated transcription factor …
of cell types and control of differentiation. Microphthalmia-associated transcription factor …
From profiles to function in epigenomics
SH Stricker, A Köferle, S Beck - Nature Reviews Genetics, 2017 - nature.com
Myriads of epigenomic features have been comprehensively profiled in health and disease
across cell types, tissues and individuals. Although current epigenomic approaches can …
across cell types, tissues and individuals. Although current epigenomic approaches can …
Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome
YG Tak, PJ Farnham - Epigenetics & chromatin, 2015 - Springer
Considerable progress towards an understanding of complex diseases has been made in
recent years due to the development of high-throughput genotyping technologies. Using …
recent years due to the development of high-throughput genotyping technologies. Using …
A LncRNA-MAF: MAFB transcription factor network regulates epidermal differentiation
V Lopez-Pajares, K Qu, J Zhang, DE Webster… - Developmental cell, 2015 - cell.com
Progenitor differentiation requires remodeling of genomic expression; however, in many
tissues, such as epidermis, the spectrum of remodeled genes and the transcription factors …
tissues, such as epidermis, the spectrum of remodeled genes and the transcription factors …
Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability
Natural hair colour within European populations is a complex genetic trait. Previous work
has established that MC1R variants are the principal genetic cause of red hair colour, but …
has established that MC1R variants are the principal genetic cause of red hair colour, but …
Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex
JS Zawistowski, SM Bevill, DR Goulet, TJ Stuhlmiller… - Cancer discovery, 2017 - AACR
Targeting the dysregulated BRAF–MEK–ERK pathway in cancer has increasingly emerged
in clinical trial design. Despite clinical responses in specific cancers using inhibitors …
in clinical trial design. Despite clinical responses in specific cancers using inhibitors …