Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Efforts to develop a consensus definition are ongoing and will greatly facilitate the
development and testing of novel interventions for sarcopenia. Although pharmaceutical …

Aging is characterized by a gradual loss of function occurring at the molecular, cellular,
tissue and organismal levels. At the chromatin level, aging associates with progressive …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Transmission of external stimuli to intracellular effector proteins via signalling …

A central question in stem cell biology is the relationship between stem cells and their niche.
Although previous reports have uncovered how signaling molecules released by niche cells …

The mechanisms contributing to sarcopenia include reduced satellite cell (myogenic stem
cell) function that is impacted by the environment (niche) of these cells. Satellite cell function …

Adaptation to mechanical load, leading to enhanced force and power output, is a
characteristic feature of skeletal muscle. Formation of new myonuclei required for efficient …

Identification of cost-effective interventions to maintain muscle mass, muscle strength, and
physical performance during muscle wasting and aging is an important public health …

Calcitonin receptor (Calcr) is expressed in adult muscle stem cells (muscle satellite cells
[MuSCs]). To elucidate the role of Calcr, we conditionally depleted Calcr from adult MuSCs …

Osteoarthritis and sarcopenia are two major joint and skeletal muscle diseases prevalent
during aging. Osteoarthritis is a multifactorial progressive degenerative and inflammatory …