During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

Apoptosis, a phenomenon that allows the regulated destruction and disposal of damaged or
unwanted cells, is common to many cellular processes in multicellular organisms. In humans …

The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or
TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The …

c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-
induced apoptosis. Multiple splice variants of c-FLIP have been described on the mRNA …

The suppressive function of regulatory T cells (T reg) is impaired in multiple sclerosis (MS)
patients. The mechanism underlying the T reg functional defect is unknown. T reg mature in …

Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or
autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to …

c-FLIP proteins (isoforms: c-FLIPL, c-FLIPS, and c-FLIPR) play an essential role in the
regulation of death receptor–induced apoptosis. Here, we demonstrate that the cytoplasmic …

Abstract CD4+ CD25+ FoxP3+ regulatory T cells (T reg) suppress T cell function and protect
rodents from autoimmune disease. Regulation of T reg during an immune response is of …

Lymphocytes of the adaptive immune system play a crucial role in defending the organism
against pathogens. Initial stimulation via antigen receptors induces activation and …

Death receptors belong to the tumor necrosis factor receptor superfamily and can induce
apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) …