With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

The processes of cellular growth regulation and cellular metabolism are closely interrelated.
The c-Myc oncogene is a “master regulator” which controls many aspects of both of these …

Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive
therapy, many patients succumb to the disease, and survivors experience severe side …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

Numerous and different types of cancers possess the dysregulation of the mevalonate
pathway as a common feature. Statins, traditionally applied in cardiovascular diseases to …

The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …

Since its discovery as an oncogene carried by the avian acute leukemia virus MC29 in
myelocytomatosis and its cloning, c-MYC (MYC), as well as its paralogs MYCN and MYCL1 …

Cancer risk reduction using pharmacological means is an attractive modern preventive
approach that supplements the classical behavioural prevention recommendations …