The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Population-level variation and mechanisms behind insulin secretion in response to
carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin …

Adaptors select cargo for inclusion into coated vesicles in the late secretory and endocytic
pathways. Although originally there were thought to be just two adaptors, AP-1 and AP-2, it …

▪ Abstract Clathrin was discovered nearly 25 years ago. Since then, a large number of other
proteins that participate in the process by which clathrin-coated vesicles retrieve synaptic …

Cellular membrane homoeostasis is maintained via a tightly regulated membrane and cargo
flow between organelles of the endocytic and secretory pathways. Adaptor protein …

Hermansky-Pudlak syndrome (HPS) is a genetic disorder characterized by defective
lysosome-related organelles. Here, we report the identification of two HPS patients with …

▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins
between various compartments of the secretory and endocytic systems. Clathrin forms a …

Lysosomes are membrane‐bound cytoplasmic organelles involved in intracellular protein
degradation. They contain an assortment of soluble acid‐dependent hydrolases and a set of …