Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

During cortical development and throughout adulthood, oligodendrocytes add myelin
internodes to glutamatergic projection neurons and GABAergic inhibitory neurons. In …

Demyelination occurs in response to brain injury and is observed in many
neurodegenerative diseases. Myelin is synthesized from oligodendrocytes in the central …

Intracellular aggregation of hyperphosphorylated Tau (pTau) in the brain is associated with
cognitive and motor impairments, and ultimately neurodegeneration. We investigate how …

Alzheimer's disease (AD) is a form of dementia characterized by amyloid-β plaques and tau
neurofibrillary tangles that progressively disrupt neural circuits in the brain. The signaling …

Leucine‐rich repeat and immunoglobulin‐like domain‐containing nogo receptor‐interacting
protein 1 (LINGO‐1), a negative regulator of oligodendrocyte differentiation and myelination …

Oligodendrocytes (OLs) form myelin sheaths and provide metabolic support to axons in the
CNS. Although most OLs develop during early postnatal life, OL generation continues in …

In Alzheimer's disease, amyloid plaque formation is associated with the focal death of
oligodendrocytes and soluble amyloid β impairs the survival of oligodendrocytes in vitro …

Low-density lipoprotein receptor-related protein 1 (LRP1) is a large, endocytic cell surface
receptor that is highly expressed by oligodendrocyte progenitor cells (OPCs) and LRP1 …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, and is caused
by multiple pathological factors, such as the overproduction of β-amyloid (Aβ) and the …