A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

Population aging is one of the most significant social changes of the twenty-first century. This
increase in longevity is associated with a higher prevalence of chronic diseases, further …

Oxidative stress is a key contributing factor in the complex degenerating cascade in
Parkinson's disease. The inhibition of MAO-B affords higher dopamine bioavailability and …

The fruits of Lycium ruthenicum Murr have long been consumed as health food and used in
folk medicine in China. Apart from the well-known polysaccharides, the active small …

This work reports the isolation of seven undescribed polyphenolic glycosides (1− 7) together
with fourteen known compounds (8− 21) from the fruit of Lycium ruthenicum Murray. The …

Alzheimer's and Parkinson's are neurodegenerative disorders that affect a great number of
people around the world, seriously compromising the quality of life of individuals, due to …

Monoamine oxidase-B (MAOB) has been believed to mediate the degradation of
monoamine neurotransmitters such as dopamine. However, this traditional belief has been …

Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration, resulting in
dopamine depletion and motor behavior deficits. Since the discovery of L-DOPA, it has been …

In light of the known neuroprotective properties of indole compounds and the promising
potential of hydrazone derivatives, two series of aldehyde-heterocyclic hybrids combining …

This review assembles evidence derived from both epidemiological and laboratory studies
that suggest exposure to aluminum salts may be more hazardous than generally …