In spite of substantial progress made toward understanding cancer pathogenesis, this
disease remains one of the leading causes of mortality. Thus, there is an urgent need to …

Background: The anthracene-9, 10-dione (anthraquinone) derivatives represent an
exceptionally valuable class in anticancer drug development. An outstanding antitumor …

Cancer has always been a dreadful disease and continues to attract extensive research
investigations. Various targets have been identified to restrain cancer. Among these DNA …

Telomerase is a ribonucleoprotein (RNP) responsible for the maintenance of chromosomal
integrity by stabilizing telomere length. Telomerase is a widely expressed hallmark …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
of synovial joints and often associated with chronic pain. Chronic joint inflammation is …

Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Cholangiocarcinomas (CHOLs), hepatobiliary malignancies, are characterized by high
genetic heterogeneity, a rich tumor microenvironment, therapeutic resistance, difficulty …

Purpose Breast cancer is the most frequently diagnosed cancer globally, and the leading
cause of cancer-associated mortality among women. The efficacy of most clinical …

Guanine-rich nucleic acid sequences are known to form G-quadruplex-four-stranded DNA or
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …

1, 2, 5-Chalcogenadiazoles (oxa-, thia-, selena-, and telluradiazoles) have been known for
many years. Their first representative, 2, 1, 3-benzothiadiazole (1), was discovered in 1889 …